The difference between nose and throat insertion for the new coronavirus nucleic acid test is that the sampling site is different and the difficulty is different. Nasopharyngeal swabs and oropharyngeal swabs can both be used as sampling methods for nucleic acid testing, and they both collect pharyngeal secretions, but nasopharyngeal swabs are sampled from the nasal cavity and oropharyngeal swabs are sampled from the oral cavity. Nasopharyngeal swabs are more complex than oropharyngeal swabs in terms of operational difficulty because the nasopharynx is not visible and requires the experience of the sampler to sample effectively without causing discomfort to the person being collected. Oropharyngeal swabs are taken by scraping the tonsils on both sides and the posterior pharyngeal wall with a cotton swab. When done properly, both sampling methods can be effective, but as swab sampling often causes nausea, vomiting, etc., making it difficult to collect secretions from the posterior pharyngeal wall, it is best to consult with a medical professional in order to avoid affecting the detection rate.