Transpupillary thermotherapy (TTT), initially used for the treatment of small choroidal melanomas, can be used for the treatment of choroidal neovascular membranes (CNV) in age-related macular degeneration. It is a new treatment that uses a semiconductor infrared laser with a wavelength of 810 nm, low radiation intensity, a large spot (1-4.5 mm), and a long time (1-10 min) to deliver the thermal energy of the laser through the pupil to the choroid, retina, and pigment epithelium through the joint and wide-angle lens on the operating microscope or through the joint and 20D lens on the indirect inspection lens. The laser heat is delivered through the pupil to the choroid, retinal epithelium and abnormal blood vessels in the fundus, causing a sustained, slow heat to seal the CNV. Studies have shown that TTT treatment can stabilize vision and occlude neovascularization in CNV patients. Complications of TTT are mainly RPE and/or choroidal atrophy, and are prone to recurrence. It is rarely used at present.