You cannot drink alcohol with quadruple therapy. Quadruple therapy is a highly effective therapy to eradicate Helicobacter pylori, which refers to the combination of four drugs: two antibiotics plus proton pump inhibitor and bismuth. Commonly used drugs include metronidazole, clarithromycin, furacilin, etc. Proton pump inhibitors mainly include omeprazole, rabeprazole, etc., and bismuth includes bismuth potassium citrate. As the treatment contains 2 kinds of antibiotics, if you drink alcohol during the treatment, you are prone to disulfiram-like reaction, which can be life-threatening in serious cases. In addition, alcohol will cause damage to the gastric mucosa, causing mucosal lesions, resulting in gastric hemorrhage and gastric perforation, so be sure not to drink alcohol during the treatment. Patients need to cooperate with the doctor’s treatment and follow the doctor’s instructions. If there is any discomfort, go to the hospital in time for treatment. Regular diet in daily life, avoid smoking, alcohol and spicy diet.