Headache after drinking alcohol can take painkillers, but after drinking alcohol to take painkillers, easy to aggravate gastric mucosal damage, the use of drugs need to be cautious. Patients who have a headache after drinking should rest more, massage the head, and need to do head imaging if necessary. You can usually drink painkillers after drinking, but patients should be cautious about taking painkillers after drinking. Because after drinking alcohol will produce stimulation of the gastric mucosa, easy to make the gastric mucosa damage and gastrointestinal vasodilatation, if the patient after drinking a headache to eat ibuprofen, acetaminophen and other painkillers are likely to exacerbate gastric mucosal damage, may be induced by stress ulcers in severe cases. Drinking alcohol after a headache is mostly considered to be the alcohol in the ethanol caused by vasodilatation caused by the patient to rest, drink more water, if necessary, can be through the massage of the head to relieve the headache. If the patient’s headache is more serious, need to do head CT or MRI examination, clear whether the headache is caused by craniocerebral lesions. It is recommended that headaches after drinking alcohol, the need for timely medical treatment, the doctor will be based on the severity of the patient’s condition to determine whether the need to take painkillers.