Calluses are relatively mild can be externally applied drugs to remove keratinization, commonly used drugs are salicylic acid cream, retinoic acid cream, severe can be surgically removed. Callus formation and this part of the long-term friction pressure caused by limited, keratotic hyperplastic damage. As age increases, the probability of callus occurrence will be higher and higher. Treatment can be conservative if it is not too serious and does not affect your life. First of all, use warm water to soak the callus to soften it, and then apply topical salicylic acid cream, vitamin A acid cream, urea ointment, etc. to remove the callus. If it is too thick with the drug effect is not good, and there is obvious pain, it is recommended that the hospital can be surgically removed. After treatment or excision, we should pay attention to improve the environment of extrusion and friction, and pay attention to the care of the skin of the hand. It is recommended to consult a dermatologist, under the guidance of the doctor targeted treatment.