Ankle sprain causing calf numbness and soreness is mainly related to nerve damage, poor blood circulation or peripheral soft tissue injury, etc. It needs to be treated according to the specific cause, such as drug therapy, physical factor therapy or surgical treatment. 1. Nerve injury: if ankle sprain is accompanied by peripheral nerve injury, it is easy to produce the symptoms of calf numbness and soreness, which belongs to the manifestation of sensory abnormality. You can consider taking medicines that nourish the nerves for treatment, such as methylcobalamin, B vitamins, etc., to promote the recovery of nerve function. 2. Poor blood circulation: Ankle sprains are prone to localized pain and swelling, affecting blood circulation, resulting in soreness and numbness in the calf, you can consider magnetic heat therapy with hot compresses or ultra-short wave treatment to promote blood circulation to relieve symptoms. 3. Peripheral soft tissue injury: ankle sprain is more serious, there has been a soft tissue injury around the joint, such as ligament tear, etc., easily accompanied by calf numbness and soreness, the need for surgical repair methods, such as ligament reconstruction surgery. Ankle sprain patients with symptoms of calf soreness and numbness, the need for targeted treatment under the guidance of a professional physician. Before the symptoms are not relieved, pay attention to rest, do not exercise too early to prevent the problem of re-sprain.