HPV infection is clinically classified into dozens of subtypes, including high-risk HPV infection and low-risk HPV infection. HPV type 45 is clinically classified as high-risk HPV infection, which may persist and lead to precancerous lesions in the cervical epithelium and even to cervical cancer. Therefore, when a high-risk HPV 45 infection is detected clinically, colposcopy should be done first to find out whether the cervical epithelium has been infected with high-risk HPV, and if there is a lesion, clinical treatment is recommended to prevent the occurrence of cervical cancer. Therefore, for HPV 45 infection, there is no need to be particularly nervous in clinical practice.