Renal insufficiency creatinine 180umol/L whether vaccination should depend on the situation, the condition is stable can be vaccinated, if the condition is not yet stable can not be vaccinated. Because kidney disease is mostly an immune system disease, because the vaccine is a heterogeneous protein, through the activation of the body’s immune response to produce antibodies, although the vaccine can protect the body to reduce the occurrence of the disease, but blindly should be possible to cause the aggravation of renal disease, delaying the progress of treatment of the disease. If the patient is currently poorly controlled primary disease, acute glomerulonephritis or etc., then the vaccination should be suspended, and the vaccination should be carried out after the condition is stabilized. Vaccination is contraindicated in patients with acute exacerbations of chronic diseases or uncontrolled severe chronic diseases. Therefore, if the patient is currently more stable, can consider vaccination, after vaccination should pay attention to observation, pay attention to observe whether the primary disease activity, creatinine level has not significantly increased. If the primary disease is active and creatinine level increases significantly after the vaccination, the patient should consult the hospital in time.