Pain in the chest, also known as subxiphoid pain, can be caused by lower esophagus, stomach, or gallbladder disease. If there is a lesion in the lower esophagus, such as early stage of esophageal cancer or Barrett’s esophagus, or bile reflux, it can cause mild pain in the chest, which needs to be further clarified by gastroscopy. If a tumor is suspected after a clear diagnosis, radical treatment of the tumor is needed, or if the lesion is benign, oral medication is needed. If it is a stomach disease, it may also lead to subxiphoid pain, such as gastritis or gastric ulcer, the examination also requires gastroscopy, which can detect the lesions inside the mucosa, and after the diagnosis is clear, oral medication can also be administered, such as omeprazole, clarithromycin, etc. Gallbladder stones secondary to chronic inflammation can sometimes lead to subxiphoid pain, which many patients mistake for gastritis, and can be detected by hepatobiliary ultrasound, which can detect stones inside the gallbladder. It is also necessary to exclude coronary heart disease, costochondritis, intercostal neuritis, etc.