Prickly heat is a seasonal, inflammatory skin condition caused by summer heat. It is mainly treated by topical or oral medications. 1. Topical medications: such as prickly heat powder, glycerite lotion, topical glucocorticoids, isotretinoin, and so on. (1) Prickly heat powder: its purpose is to inhibit the regeneration of prickly heat, in addition to anti-inflammatory, anti-itching, analgesic effect. Be careful not to apply too much so as not to block the pores. (2) Glycerite lotion: If the itching symptoms are obvious, you can use glycerite lotion to relieve the itching symptoms and reduce swelling and redness. (3) Topical glucocorticoids: such as tretinoin cream, suitable for patients with red prickly heat, the purpose is to control inflammation and reduce itching. (4) Isotretinoin: It is suitable for patients with deep prickly heat and aims to inhibit the regeneration of prickly heat. 2. Oral medications include antihistamines and antibiotics. (1) Antihistamines, such as loratadine and cetirizine, are used to relieve inflammation and itchy skin. (2) Antibiotics: e.g. penicillin, erythromycin, clindamycin, etc., are suitable for patients with inflammation of skin damage and accompanied by infection. If prickly heat is diagnosed, it is recommended to go to the hospital in time, under the guidance of the doctor for standardized treatment, and follow the doctor’s instructions for medication.