What are the goals of polycystic ovary treatment and how should treatment be “tailored to the individual”?

  ”Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Sporadic menstruation, hirsutism, obesity, and acne are typical symptoms of the disease.” This is the most common explanation of polycystic ovary syndrome from health websites. Some people get it right as soon as they see this explanation. Other patients, who find that some of the symptoms don’t match up, are suspicious of the clinician’s diagnosis. Recently, a reader, Luo Min (pseudonym), sent an email about polycystic ovary syndrome.  Is the cause of menstrual disease “polycystic”?  Luo Min is 24 years old. When it comes to her polycystic ovary syndrome, it starts with her menstruation. It is known that her menstruation has been inaccurate since her first period. She was 15 years old when she had her first period, and at that time, her periods were particularly heavy and long.  So, Luo Min ran to the hospital, the doctor gave her a patch of Chinese medicine, after eating Chinese medicine menstruation is no longer, since then it is still relatively normal. Later on, somehow, menstruation slowly became once every two months, and at the age of 17, it came twice a year.  At the age of 17, Luo Min went to see a doctor, who said it was caused by the stress of studying, and said that it would get better slowly. So at that time did not particularly care. As a result, the study has been more intense, so not much treatment of menstrual disease.  It was only when she was 20 years old and the pressure of studying was a little lighter that Luo Min began to pay attention to the treatment of menstrual disorders. This time, Luo Min went to see a Western doctor and was diagnosed with polycystic ovary syndrome. She was a little confused by this diagnosis, because the Internet says that only fat people suffer from “polycystic”. But she was very thin and only had more hair.  In order to cure the disease, Luo Min did not say anything, under the guidance of the doctor. She first ate a year of Daying, and her periods were normal that year, but she stopped after hearing that eating too much was not good. Therefore, another Chinese doctor was found for Chinese and Western medical treatment. At that time, the western medicine was clomiphene tablets. The effect was quite good, but if she stopped taking it that month, her period would not come.  When she consulted the doctor, he told her, “When you get married and have children, your period will be normal.” This explanation didn’t satisfy Luo Min at all. “I’m not even ovulating now, how can I have a baby when I haven’t had a period in over a year?” Luo Min wrote in an email.  ”I don’t know what to do, I hope you can help me, thank you.”  ”Polycystic” is not the patent of fat people With Luo Min’s question, the reporter interviewed Dr. Zhao Hongli, deputy director of the Department of Chinese Gynecology of Hangzhou Hospital of Traditional Chinese Medicine. Dr. Zhao analyzed that there are indeed many misconceptions about polycystic ovary syndrome, and he often encountered many patients who think that only fat people suffer from “polycystic” in the outpatient clinic. In fact, this is not true.  ”Currently, the 2003 Rotterdam criteria are used in China, namely: 1. sporadic ovulation or anovulation; 2. clinical manifestations of hyperandrogenism and/or hyperandrogenemia; 3. polycystic ovarian changes: ≥12 follicles of 2-9 mm in diameter in one or both ovaries, and/or Ovarian volume ≥ 10 ml. 4. The diagnosis of PCOS can be made after 2 of the above 3 items are met and other causes of hyperandrogenemia are excluded (congenital adrenocortical hyperplasia, Cushing’s syndrome, androgen-secreting tumors, etc.). Whether these diagnostic criteria are suitable for Chinese people remains to be studied.  It can be seen that there is no relationship between the diagnosis of polycystic ovary syndrome and people’s fat and thinness.  Dr. Zhao also told reporters that polycystic ovary syndrome is the most common endocrine disease in women, affecting 5-10% of women of childbearing age, accounting for about 1/3 of the menstrual patients in Dr. Zhao’s clinic. The purpose of treatment should be divided into near-term and long-term, and the treatment should be “tailored to the individual”. PCOS has a diverse and heterogeneous clinical presentation, and the specific needs of each patient are different. Each patient’s specific needs are different, so clinicians should distinguish between the main and secondary conflicts in treating this disease, and “tailor the treatment to the individual,” which means that the treatment should be individualized according to the patient’s specific situation. Dr. Zhao said.  For example, for patients who are eager to get pregnant. These people can increase their chances of pregnancy by opting for ovulation-promoting treatment. On the contrary, for those without fertility requirements, ovulation-promoting drugs such as clomiphene and HMG should not be used because excessive application of ovulation-promoting drugs can deplete ovarian reserves and, according to some reports, may also increase the risk of ovarian tumors.  In the case of Luo Min, Dr. Zhao believes that she is very young and if she does not have any current fertility requirements, treatment with clomiphene is unnecessary. As for Dain 35, although it can control menstruation and has a certain hypoandrogenic effect, after stopping the drug, the symptoms often return to the old, often treating the symptoms but not the root cause. This kind of patients can basically restore the normal reproductive endocrine state through proper Chinese medicine regulation, and have independent ovulation to achieve a more ideal treatment purpose.  Dr. Zhao also reminded that while treating, one must pay attention to adjusting the lifestyle, reasonable diet structure, and insist on exercise. According to research findings, polycystic ovary syndrome often also has insulin resistance, which is related to metabolic diseases such as type 2 diabetes and abnormal lipid metabolism.  This means that if your elders have diabetes, then the probability of you having polycystic ovary syndrome is also high. Of course, even if no one in your relatives has diabetes, but you are a big fish and don’t like to exercise every day, it is still possible to develop metabolic diseases.  Like other patients with metabolic diseases, they have insulin resistance, whether they are thin or fat. In the treatment, if, they can change their lifestyle or apply insulin sensitizers to treat them, it will be effective. Lifestyle changes include eating less fried and high cholesterol foods, keeping your mouth shut and moving your legs.