Gastric impression cell carcinoma has a low probability of being missed because it has a characteristic morphologic structure. Gastric impression cell carcinoma is an adenocarcinoma with higher malignant degree, and after staining, it has a unique appearance, with the form of a ring, so as long as the operation of pathological examination is standardized and the doctor is experienced, it is seldom to be diagnosed by omission. Of course, there is a correlation between the leakage of diagnosis and the material taken under gastroscopy, and when the material taken is small, it is often impossible to diagnose. Therefore, when gastric cancer is considered clinically, if less material is taken, the material should be taken again, which can reduce the probability of missed diagnosis. Therefore, the probability of missed diagnosis is still very low with adequate sampling, standardized pathological examination operation and unique manifestations of gastric impression cell carcinoma.