Some patients with insulin resistance may not have characteristic manifestations. Some patients may have acanthosis nigricans, preprandial hypoglycemia, etc. Consultation with a doctor is recommended. Some patients with insulin resistance may not have characteristic manifestations. Some patients may have acanthosis nigricans, which may appear in the folds and neck papillomatous and velvety melanosis and hyperkeratosis and other related symptoms; at the same time, if the patient does not eat on time, there may also be preprandial hypoglycemia, such as panic, cold sweats, hand tremors, etc. In addition, insulin resistance is often combined with blood lipids and blood sugar. In addition, insulin resistance patients are often combined with elevated lipids, obesity, atherosclerosis and other conditions. Patients with insulin resistance are advised to go to the hospital and ask the doctor to make a judgment.