Urine protein 4 plus indicates that the patient’s urine contains a lot of protein, which may be related to diabetic nephropathy or nephrotic syndrome, and the main treatment is medication. 1. Diabetic nephropathy: If it is caused by diabetic nephropathy, then it means that the kidney damage is more serious. In this regard, we should actively control blood sugar, and can take some ACEI or ARB drugs, such as enalapril maleate tablets, irbesartan tablets, etc., appropriately, to control the content of urinary protein, so as to improve the function of the kidneys. 2. Nephrotic syndrome: it may be related to secondary damage such as allergic purpura or systemic lupus erythematosus, which should go to the hospital in time to receive further examination and take some hormone or immunosuppressant drugs under the guidance of the doctor, such as prednisone acetate tablets, cyclosporine and so on, so as to effectively alleviate the condition. For urine protein 4 plus patients, it is recommended to timely hospital consultation, clear causes of urine protein, standardized treatment under the guidance of the doctor.