Warfarin overdose is prone to spontaneous bleeding, and a variety of bleeding manifestations are common. If the dosing time is short, less than 1 hour, gastric lavage can be performed. If the drug has been taken for a long time or is accompanied by bleeding symptoms, such as vomiting blood, tarry stools, bruising under the skin or neurological symptoms caused by cerebral hemorrhage, etc., regardless of the value of INR, immediate medical attention should be sought because warfarin is metabolized slowly and hospitalization is recommended for observation of the condition to avoid aggravation. Clinical treatment starts with discontinuation of the drug, often with intravenous vitamin K and thrombin to neutralize the anticoagulant effect of warfarin and, if necessary, with whole blood or plasma transfusion therapy. At the same time, injury bleeding should be avoided to avoid bleeding and difficulty in stopping the bleeding due to warfarin overdose leading to disorders of the coagulation system.