Cracked and peeling thumbs with hard skin need to be identified and treated first. Thumb cracking and peeling with hard skin may be related to dry skin, callus, lack of fat eczema and so on. It is recommended that patients go to the hospital in time to clarify the cause of the disease, the cause of treatment. 1. Dry skin: long-term dehydration of the skin, resulting in damage to the skin barrier. Mainly manifested as dryness, roughness, flaking, dry cracks and other symptoms. Urea, lactic acid, glycolic acid and glycerin can be used to apply to the affected area. 2. Callus: formed due to long-term contact with friction, resulting in hyperkeratosis and thickening of keratin. Daily use of warm water to soak the affected area or the use of sulfur salicylic acid ointment, Vitamin A acid ointment, etc. to apply to the affected area, soften the keratin. 3. Lack of fat eczema: the skin can be manifested as light red, superficial cracking, with mild flaking. Hydrocortisone, dexamethasone cream and other topical medications can be used. It is recommended that patients go to the hospital in time to clarify the cause of the disease. If you need to use drugs, you need to use under the guidance of a doctor.