The first sealing of root canal and pain at night needs to be judged according to the sealed drug. If it is pulp inactivator, observation is recommended; if it is root canal disinfectant drug, ibuprofen relief capsule can be taken to relieve the pain, and it is recommended to go to the hospital for consultation. 1. Pulp inactivator: Commonly used in the first sealing of pulpitis in posterior teeth. Pulp inactivator drugs will lead to increased exudation of blood vessels in the pulp, congestion, and increased pressure inside the pulp cavity, resulting in pain. Observation is recommended, usually with the necrosis of the pulp will gradually relieve. If the pain is severe, it is recommended to consult a doctor in time to remove the inactivator to reduce the pressure in the pulp cavity and relieve the pain. 2. Root canal disinfection medication: commonly used in root canal disinfection after root canal preparation, the pain may be caused by missing root canals or medicated periapical inflammation, you can take ibuprofen extended-release capsules for pain relief, and it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, to look for the missing root canals or to change the medication, in order to prevent the aggravation of the condition. Root canal system is complex, it is recommended to go to the regular hospital stomatology department.