Drinking alcohol after the hepatitis B vaccine is not recommended. Although drinking alcohol is not thought to cause the failure of the hepatitis B vaccine, or a significant decrease in activity, drinking alcohol has the potential to cause a more uncomfortable reaction in patients. After all, the vaccine is foreign and there is a possibility of adverse reactions after the injection. If there is a slight fever and gastrointestinal discomfort, it is possible that the gastric mucosa may be stimulated by alcohol and develop a more pronounced gastritis, or even an ulcer, leading to stomach pain. If these adverse reactions do not occur, a little alcohol is not enough to cause uncomfortable symptoms. The hepatitis B vaccine is actually hepatitis B surface antigen, a product of genetic recombination, which, when injected into the body, causes the body to produce surface antibodies to hepatitis B. Hepatitis B surface antigen is not very sensitive to alcohol or other disinfectants in an in vitro environment, and alcohol does not inactivate the hepatitis B surface antigen. When the hepatitis B vaccine is injected into the body, even if a person drinks a large amount of wine with a particularly high alcohol concentration, it is not so much as to inactivate the active ingredient in the vaccine mass, but it is not recommended to drink a large amount of wine after the hepatitis B vaccine is injected.