Hepatitis A and E negative and high ghrelin may be suffering from autoimmune hepatitis, alcoholic hepatitis, drug liver injury and other problems. 1. Autoimmune hepatitis: mostly caused by autoimmune diseases such as lupus erythematosus, due to autoimmune dysfunction of the body, resulting in immune cells infringing on normal liver cells, hepatitis A and hepatitis E negative ghrelin is high. 2. Alcoholic hepatitis: long-term drinking or drinking too much alcohol at one time, alcohol can not be completely metabolized by the liver, thus causing alcoholic hepatitis, affecting the normal liver function, and hepatitis A and hepatitis E negative ghrelin transaminase is high. 3. Pharmacological liver injury: to understand whether recently ate on the liver damage to the drug. Such as anti-tuberculosis drug rifampicin, hyperthyroidism medication methimazole and so on have certain damage to the liver, thus appearing glutamic acid aminotransferase is high. Hepatitis A and E are negative, but high ALT should be analyzed in the context of the specific situation, and it is recommended to go to the hospital in a timely manner to clarify the cause of the disease and then give targeted treatment.