1.Is it normal to leak fluid after using medicine? Leakage of some medicine after using enema solution is normal, usually because the enema solution into the intestinal tract will cause some patients to produce a sense of defecation, which will improve until it stops when the symptoms of the acute phase of colitis begin to ease. If the patient has had leakage when using the enema solution, incontinence pads can be used so that you no longer have to worry about leakage at night. 2.Is it normal to feel pain when using the medicine? There is usually no pain when using the drug delivery device. Some patients may experience discomfort, which can be relieved by applying lubricant to the drug delivery tube or placing the tube in warm water to preheat it before administration, and try to stay relaxed during the drug delivery process. 3.Is it difficult to keep the enema solution in my body for a long time before I need to go to the bathroom? Often patients want to go to the bathroom immediately after the first use of the enema solution. Even so, patients should continue treatment so as to maintain the efficacy of the enema. Usually the patient’s ability to retain the enema for a week or so increases. To keep the enema in the body as long as possible, try to relax as much as possible. Better results are obtained by emptying the bowel before using the enema. Place a towel on the bed and try to remove the pressure of rectal discomfort while trying to read, listen to music or watch TV. If the patient still has this trouble after a week or 10 days, you can talk to your doctor about it.