Sleeplessness is a difficulty in falling asleep. Generally, if the time from going to bed to fall asleep is more than half an hour, it is a kind of insomnia, which is also the most common type of sleep disorder. First, we need to clarify whether the patient’s sleep environment is abnormal, such as noisy environment, bright light stimulation, abnormal smell, or too hot, air circulation, etc., after excluding these external environmental causes. Secondly, it is necessary to clarify whether the patient has emotional disorders, such as anxiety, depression state, if the patient thinks about things more, usually stressful, bad mood, often lead to difficulties in sleeping. For this situation, sleep-promoting drugs can be used, and the new class of non-benzodiazepine sleeping drugs, such as dexrazopiclone, Synthroid and zopiclone, are recommended. If the patient’s combined anxiety and depression are obvious, anti-anxiety and anti-depressant drugs such as haloperidol melitrexin, duloxetine and escitalopram oxalate can be used at the same time.