Pain in the lumbar and sciatic nerves may be due to a herniated lumbar disc stimulating the nerve roots, resulting in radiating pain in the lower extremities; or pear-shaped muscle syndrome resulting in sciatic nerve stimulation, and pain in the lumbar and sciatic nerves, the following drugs can be taken. First, non-steroidal anti-inflammatory painkillers, such as nimesulide, diclofenac sodium enteric capsules, clonoxicam, these drugs can play a role in reducing local inflammatory stimulation, nerve irritation is reduced after the pain symptoms can be significantly reduced. Secondly, muscle relaxants, such as Eperisone Hydrochloride tablets, can effectively relax the surrounding muscle tissue, relieve pain and have obvious discomfort related feelings. Third, you can take oral nerve-nourishing drugs, such as methylcobalamin tablets, which can play the role of nerve nutrition and promote the recovery of nerve function. Fourthly, it is the drugs that activate blood circulation and improve circulation, such as sodium hepaticoside tablets and dibazol tablets, which can effectively improve the local venous reflux and promote the metabolism and absorption of local inflammatory metabolites, helping to relieve the symptoms.