Sleeping at night with a feeling of pressure on the heart gasping for air may be related to coronary heart disease, heart failure, reflux esophagitis, etc., need to be on the cause of drug or surgical treatment. 1. For coronary heart disease, you can follow the doctor’s instructions oral clopidogrel and other antiplatelet drugs, risuvastatin or fenofibrate and other lipid-lowering drugs; drug treatment is ineffective, feasible percutaneous coronary intervention, coronary artery bypass grafting and so on. 2. For heart failure, oral diuretics such as furosemide, angiotensin-converting enzyme inhibitors such as captopril, beta-blockers such as metoprolol and digitalis drugs such as digoxin can be taken as prescribed by the doctor; for those who are not effective in conservative treatments, implantation of left ventricular assist device can be considered. 3. For the reflux esophagitis caused by, can follow the doctor’s prescription oral omeprazole and other proton pump inhibitors, domperidone and other gastric stimulation drugs; drug treatment effect is not obvious, can consider anti-reflux surgery or laparoscopic gastric fundoplication. It is recommended that people who sleep at night with a feeling of pressure on the heart can not breathe go to the regular hospital in time, clear cause, standardized treatment under the guidance of the doctor, avoid self-medication.