Enlarged lymph nodes in the armpit may be caused by lymphadenitis, immune system diseases, tumors and other diseases, which need to be judged according to the patient’s symptoms. 1. Lymphadenitis: If the patient finds that the enlarged lymph nodes are accompanied by redness, heat and pain, it may be lymphadenitis, which can be treated with oral anti-infective drugs, such as amoxicillin, azithromycin and so on. 2. Immune system diseases: common immune system diseases such as AIDS, this kind of disease may cause patients with enlarged lymph nodes all over the body, to the neck, armpits or inguinal area, in addition, this kind of disease will also be accompanied by anemia, systemic fever and other symptoms, the treatment of anti-infective symptomatic treatment, including tenofovir, lamivudine, and other drugs. In addition, connective tissue diseases, such as systemic lupus erythematosus, tuberculosis, etc., can also lead to multiple lymph node enlargement in the armpit. 3. Tumor. If the patient’s enlarged lymph nodes are painless, after excluding the above diseases, we need to consider lymphoma, malignant tumor metastasis and other causes. At this time, metastasis to the axilla, resulting in enlarged lymph nodes, have the characteristics of hard texture, painless, not easy to push, and easy to appear fusion. It is recommended that the patient should consult the doctor in time and follow the doctor’s instructions to choose the treatment plan after a clear diagnosis. It is recommended that patients go to the hospital in time to clarify the cause of enlarged lymph nodes as soon as possible, and choose the appropriate treatment plan under the guidance of the doctor.