Taking Vimofenib, usually about 5~12 months can not be taken, the specific time can not be generalized, usually after the occurrence of disease progression or the occurrence of unacceptable toxicity reaction and other drug-resistant reactions to stop the drug. Vemofenib is mainly used for BRAF V600 mutation-positive, and mainly for the treatment of unresectable and metastatic melanoma; after the use of the drug, the drug needs to be continued until the disease progresses or the occurrence of unacceptable toxicity and other drug-resistant situations before discontinuing the drug. For example, the occurrence of adverse events with symptoms or prolongation of the Q-Tc interval, the occurrence of adverse events in squamous cell carcinoma of the skin. Usually, drug resistance rarely occurs within 5 months, while drug resistance reactions may occur around 5 to 12 months; therefore, the general discontinuation time is around 5 to 12 months, but the specific discontinuation time cannot be generalized, and needs to be decided by the doctor after a comprehensive assessment in conjunction with the medical condition. The drug may cause liver damage, neutropenia and other discomforts, allergic to the components of the drug is prohibited; before taking the drug, under the guidance of a doctor to carry out the BRAFV600 mutation test, and the results of the positive before using the drug; pregnancy, breastfeeding, and other special groups of women, need to be guided by a doctor to use the drug. All of the above medications should be used under the guidance of a doctor, avoid self-medication, in order to avoid adverse consequences.