Syphilophobia is essentially a phobia of syphilis. In clinical practice, psychotherapy or medication is generally used to treat this condition. Psychotherapy often uses cognitive behavioral therapy, including imaginal exposure. Through imaginal exposure the patient is able to perceive increased levels of anxiety and fear, which tend to decrease naturally. This cognitive-behavioral approach helps patients to reduce the painful experience of fear and anxiety and ultimately achieve the goal of treatment. The main medication used is anxiolytic or antidepressant drugs such as benzodiazepine anxiolytics, lorazepam, alprazolam or 5-hydroxytryptamine reuptake inhibitors paroxetine, sertraline, etc. The treatment is effective.