Mesenchymal tumors at the lesser curvature of the stomach are gastrointestinal mesenchymal tumors (GIST), which are tumors with potential malignant potential. Gastrointestinal mesenchymal tumors can occur anywhere in the digestive system and are tumors with malignant potential. As the disease progresses, almost all tumors develop malignant behavior. If the size keeps increasing, generally the higher the malignant potential of the tumor, the greater the lethality may be. Depending on the size, location, and growth pattern of the gastrointestinal mesenchymal tumor, clinical symptoms such as abdominal pain, nausea and vomiting, weight loss, and abdominal masses may occur. As the disease progresses, it may also lead to gastrointestinal bleeding, gastrointestinal perforation, gastrointestinal obstruction, and multiple liver metastases. It is recommended that asymptomatic and small gastric curvilinear mesenchymal tumors should be left untreated and tested regularly; if the tumor is large in size or grows rapidly, and obvious clinical symptoms have appeared, then timely surgical resection of the tumor is needed.