Misoprostol tablets are sublingualized for rapid drug action in a short period of time. Misoprostol belongs to the class of prostaglandins and is often used to inhibit the secretion of gastric acid and prevent the development of ulcers. In gynecology misoprostol can be used in combination with mifepristone to terminate early intrauterine pregnancy. The main effect of misoprostol is to promote contractions and the expulsion of the gestational sac. Sublingual is a method of taking the drug, because the sublingual has rich capillaries, through the sublingual absorption of the drug into the blood circulation can be quickly absorbed, to avoid the first-pass effect of the liver can be faster and better to play the efficacy of the drug. Taking misoprostol tablets either for the treatment of gastric diseases or for gynecology should be taken in strict accordance with the doctor’s instructions in order to avoid triggering or aggravating the occurrence of adverse drug reactions, and secondly, we should pay attention not to take and other drugs at the same time.