Urine protein 3+ for renal puncture examination is mainly to clarify the cause of the disease, if the patient’s cause is clear, generally do not need to do renal puncture examination. If the cause of urine protein 3+ is clear, for example, the patient has a history of diseases such as diabetes mellitus or hypertension, which develops due to complications, there is generally no need to do renal puncture examination, because renal puncture examination is invasive. If the cause of urinary protein 3+ is not known, simply with urinary protein can not determine the disease, then you need to perform pathological examination by renal puncture examination to clarify the cause of urinary protein. Clinical causes of urine protein 3+ include chronic glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, drug-induced renal injury, hepatitis B-related nephropathy, myeloma-related nephropathy and so on. If the urine protein 3+ suggests that the patient to the regular hospital in time, and under the guidance of the doctor to improve the relevant examination to clarify the cause of the disease, targeted treatment.