Alternating day therapy is the endocrinologist’s way of supplementing low corticosteroids because corticosteroid secretion has a circadian rhythm, with a peak and high point of secretion between 8 and 10 a.m. each day, followed by a gradual decline and a minimum peak at 24 p.m. This is triggered by the circadian rhythm of corticosteroids, so the medication can be administered according to this rhythm. In long-term treatment regimens, chronic diseases can be treated with alternate-day dosing, where a one-day dose or a two-day dose is given to the patient once every other morning. This is when endocrine hormone secretion is at its peak, so there is less suppression of adrenocortical function and fewer therapeutic side effects for the patient, which is the alternate day treatment method.