Immunosuppressants and hormones which side effects are greater can not be generalized, the size of the two side effects and the dosage and duration of the medication, can not be directly compared. Immunosuppressant side effects: myelosuppression is the most common side effect of immunosuppressants, mostly seen in the early stage of treatment, can cause granulocytopenia or deficiency; cause liver function damage, resulting in elevated aminotransferases; will impair sexual function, resulting in hypogonadism, and a small number of infertility can occur. Immunosuppressants may also cause headache, limb tremor, sensory disorders and visual impairment and other side effects, and even lead to the occurrence of secondary tumors. Hormone side effects: long-term use of hormones may cause calcium loss, resulting in osteoporosis; will damage the gastric mucosa, which may lead to gastric ulcers; the use of hormones by the physically weak, the immune system ability to weaken, resistance to decline, easy to be infected by bacteria and viruses and fall ill, and so on. Long-term oral hormones may cause side effects such as damage to the digestive mucosa, osteoporosis, osteonecrosis of the femoral head, and Cushing-like syndrome. In general, the risk of adverse reactions increases with the increase of time and dosage of medication. The side effects of immunosuppressants and hormones are related to the dosage of medication and the time of use, and the two cannot be directly compared. It is recommended that patients follow the doctor’s instructions after a clear diagnosis, to avoid self-medication, resulting in adverse consequences.