Persistent obesity mainly refers to the gene-sparing type of obesity, which is more difficult to treat and needs to be treated with drugs. It mainly has the following characteristics: 1. high efficiency of energy utilization; 2. particularly good appetite, and in the short term, through diet control and with exercise treatment, negative energy balance occurs and the patient’s weight will drop. However, for various reasons, it is difficult for the patient to adhere to the control of diet for a long time, and the weight can rebound, even heavier than before the weight loss. In order to lose weight, it is necessary to change the inactive lifestyle and to increase exercise to burn excess calories.