Callus on the feet is also known as callus, no obvious symptoms of conservative treatment, such as drug therapy, physical therapy; if the pain is obvious impact on life, can be surgical treatment. 1. Drug therapy: all drugs need to be used under the guidance of a doctor. (1) Urea: often choose urea ointment, urea cream, etc., has a very good moisturizing effect, can remove excess keratin on the surface of the skin, thus softening the callus. (2) Salicylic acid: such as salicylic acid ointment, etc., can relieve the pain caused by foot calluses. (3) Vitamin A acid drugs: such as vitamin A acid ointment, etc., which can remove the excess keratin. 2. Physical therapy: including liquid nitrogen therapy, which can also remove the local excess keratin proliferation, thus relieving the symptoms; toe orthotics, which can improve the bones of the foot and reduce the skin irritation and friction, thus avoiding the skin over-keratinization aggravating the formation of callus. 3. Surgery: mainly for people with foot deformity and pain that affects daily life, metatarsal and callus excision, metatarsal shortening surgery can be chosen to improve the bone deformity and correct bunion, so as to treat the callus. It is recommended that patients go to the hospital in time, according to the condition under the guidance of the doctor for appropriate treatment.