If antinuclear antibodies are negative, follow-up treatment is still needed if the disease is being treated, but if the disease is not present, there is no need for treatment, and follow-up observation can be made. Antinuclear antibodies generally play an auxiliary role in the diagnosis of autoimmune diseases, autoimmune diseases such as systemic lupus erythematosus, desiccation syndrome, etc. Antinuclear antibodies can be found in the serum, and a small number of normal people can also have a low titer of positive antinuclear antibodies. If you have autoimmune disease such as SLE, dry syndrome, etc., and are under treatment, then even if the antinuclear antibody is negative, you still need to continue treatment and follow-up review. If the test was positive for antinuclear antibodies and there is no related autoimmune disease, then the antinuclear antibodies will become negative and no further treatment is needed. If you have autoimmune disease, you can’t pursue antinuclear antibody conversion, you need to observe the activity of the disease, and even if the antinuclear antibody conversion is negative, you need to actively consult a doctor for formal diagnosis and treatment.