Closed mouths and whiteheads grow because the sebaceous glands produce too much oil and the hair follicles are clogged so that the oil can’t be discharged and accumulates inside the follicles to form closed mouths and whiteheads. They can be removed through general treatment, medication, and medical cosmetic treatment. 1. General treatment: long closed mouth and whiteheads can not be squeezed by hand, with water or suitable for their skin type of cleansing products to remove excess oil on the skin surface, dandruff and bacteria mixture, pay attention to oil control and moisturizing. You should also avoid the intake of high sugar and high fat diet, avoid staying up late, adhere to a period of time closed mouth and whiteheads will disappear. 2. medication: you can take oral retinoic acid capsules to inhibit the secretion of sebaceous glands, you can also take oral minocycline hydrochloride tablets and other antibiotics to help treatment. For topical medication, you can choose adapalene gel, retinoic acid cream and so on to treat. 3. Medical aesthetic treatment: fruit acid peeling, photorejuvenation, photodynamic and other dermatological aesthetic techniques can also be used for treatment. The use of drugs need to follow the doctor’s instructions, it is recommended to go to the hospital dermatology department in a timely manner, under the guidance of the doctor to choose the appropriate treatment, do not do it on their own, so as to avoid improper treatment to affect the aesthetics or complications.