Amoxicillin and clarithromycin can be taken at the same time for the treatment of gastritis caused by Helicobacter pylori, but it is necessary to exclude contraindications and pay attention to adverse reactions. Amoxicillin is a penicillin drug, clarithromycin is a macrolide drug, these two drugs are used in combination with omeprazole capsules and bismuth pectin, which can be used to eradicate gastric and duodenal Helicobacter pylori bacteria, and at the same time can reduce the rate of recurrence of peptic ulcers. They can be taken together. In case of serious adverse reactions such as vomiting, pseudomembranous enteritis, asthma, anemia, thrombocytopenia, and abnormal behavior while taking the medication, it is recommended to discontinue treatment with the medication and go to the hospital. This regimen is contraindicated for positive skin test for either drug, pregnancy as well as lactating females, severe hepatic dysfunction, ongoing use of terfenadine, cardiac conduction abnormalities, congestive heart failure. The need to combine amoxicillin and clarithromycin requires a comprehensive decision by the clinician, and unauthorized use of the drugs is prohibited.