Eardrum pain when flying is mainly due to abnormalities in the function of the eustachian tube at the exit of the ear, resulting in eardrum irritation when the airplane rises or descends with a particularly pronounced mismatch of atmospheric pressure inside and outside the eardrum. You can chew gum or swallow saliva continuously when the airplane is rising or descending. If there is poor nasal ventilation in the early stage, you can apply drugs to improve nasal ventilation, such as furosemide nasal drops, cochlear or endosulfan, for a short period of time before taking the airplane. If you can hold your breath for a long time, you can pinch your nose, close your mouth and cover your ears when the airplane is ascending and especially descending, which will not lead to the change of atmospheric pressure inside and outside the eardrum, and can relieve eardrum pain.