Zoledronic acid can be used to treat breast cancer, the use of zoledronic acid in breast cancer patients may be fever and many other adverse reactions, the use of medication should be guided by a physician. Zoledronic acid is mainly used for the treatment of bone pain caused by osteolytic bone metastases of malignant tumors, and it has an anti-tumor effect, but the ABCSG-12 study found that the addition of zoledronic acid to endocrine therapy for breast cancer patients with a high rate of recurrence can, to a certain extent, reduce the rate of breast recurrence and risk of death. Currently there is clinical use of zoledronic acid to some breast cancer patients in the treatment program. However, zoledronic acid should not be abused by breast cancer patients; it may cause adverse reactions such as fever, malaise, chest pain, nausea and vomiting, low blood pressure, and anemia. It is contraindicated for patients who are allergic to this product or other bisphosphonates, pregnant and lactating women, and is not recommended for those with severe renal insufficiency. Application of zoledronic acid should be guided by professional doctors. It is recommended that breast cancer patients go to the hospital in time, so that the doctor can determine the treatment plan according to the condition.