Macular edema is usually effective in one week after the injection. Macular edema is an inflammatory reaction in the macula, the most light-sensitive part of the retina at the bottom of the eye, as fluid leaks in to form an edema, causing a severe loss of vision. Macular edema occurs secondary to a variety of eye diseases and should be treated symptomatically. In severe cases, intraocular injections of tretinoin can be given for about a week to relieve the edema, and vision can be restored to varying degrees. However, it should be noted that Trigonelline injection belongs to the glucocorticoid, injection is likely to lead to secondary glaucoma, intraocular pressure increases, patients with eye swelling and pain and other uncomfortable symptoms, it is recommended that patients should always monitor the intraocular pressure after the injection, intraocular pressure, if the pressure is too high, it should be timely application of intraocular pressure lowering medication or go to the hospital to ask the doctor.