The fossa in the middle of the clavicle is painful on pressure and may be caused by several reasons: 1. Injury here. This area is very fragile, with only a very thin layer of fat under the skin, and further down, the softer trachea and esophagus. If you suffer a minor impact, it may cause a very serious injury, there will be obvious pressure pain. 2, thyroid-related lesions. For example, the presence of goiter, especially swelling in the isthmus of the thyroid gland, may lead to pressure pain here. In addition, diseases such as thyroid nodules and thyroid cancer may also cause similar symptoms. 3. Diseases related to the larynx. For example, inflammation or infection in the larynx may also cause pressure pain. 4. Infection. If there is some subcutaneous infection, such as cellulitis, there will be very obvious pressure pain.