Common side effects of H. pylori quadruple therapy include indigestion, black stools, acid reflux and heartburn. 1. Dyspepsia: mostly caused by inhibition of gastric acid secretion by proton pump inhibitors, resulting in insufficient gastric acid secretion and weakened digestion of food. In daily life, we should pay attention to the dietary habits and adjust the dietary structure. 2. Black stools: mostly caused by taking bismuth, which can cause black stools and black tongue. Generally, it can return to normal after stopping the medicine and does not need special treatment. 3. Acid reflux and heartburn: may be due to taking antibiotics to stimulate the gastrointestinal tract, thus causing acid reflux. Generally, no special treatment is needed, and it can return to normal after stopping the medicine. H. pylori side effects can have many manifestations, according to the specific manifestations of the symptomatic treatment, serious symptoms are recommended to consult a doctor in a timely manner, follow the doctor’s advice.