Inability to hold in urine may firstly be caused by holding in urine for a long period of time and does not require treatment. Secondly, it may also be caused by overactive bladder, for male patients also need to consider is caused by prostate hyperplasia, patients need to take general measures to deal with, as well as drug treatment, surgical treatment. 1. Prolonged urinary holding: if the time of holding urine is relatively long, it will lead to the performance of the patient can not hold urine, which is a normal physiological phenomenon, do not need to be treated. 2. Overactive bladder syndrome: Overactive bladder syndrome will lead to urge urinary incontinence, urinary urgency and other manifestations, so the patient will be unable to hold urine. In addition, patients also need to carry out pelvic floor muscle training, urine-holding training and so on. Patients need to use M receptor blockers, such as oxybutynin, solinacin, etc. under the guidance of the doctor. 3. Prostatic hyperplasia: Patients with prostatic hyperplasia will experience urge incontinence, urinary urgency and other manifestations. Patients can’t hold their urine. Patients need to follow the doctor’s instructions with alpha-blockers, such as doxazosin, terazosin and so on. Some patients can also be treated with transurethral prostate electrocision and transurethral prostatectomy. Patients should consult a doctor for examination in time when they can’t hold their urine, for excluding physiological factors that cause urine can’t hold it need to consult a doctor in time, follow the doctor’s instructions for treatment, the drug should be applied under the guidance of the doctor.