Pregnancy toxemia in dairy cattle is also known as ewe obesity syndrome, fatty liver in cattle and ketosis in obese cattle. The cause of this disease is a combination of digestive, metabolic and reproductive dysfunctions caused by high energy levels in the diet of dry milk cows and fattening of cows. Clinically, it is characterized by loss of appetite, cessation of gastrointestinal motility, and intermittent jaundice. Sick cattle exhibit ketosis, progressive weakness, neurological symptoms, mastitis and recumbency. The mortality rate is high, and the autopsy reveals severe fatty degeneration of the liver and kidneys. 1, epidemic characteristics dairy cattle pregnancy toxemia often occurs in a certain region, certain cattle farms, the epidemic is regional, sick cattle single appearance, distribution. Occasionally, the disease is seen in postpartum cows over a period of time. It occurs in all litters. Among them, 78.9% of the 1-6 litters and 21% of the 6-10 litters, i.e., young cattle and cattle with low litter size have more incidence. The disease can occur throughout the year, of which 55% from December to May of the following year and 45% from June to November, i.e. more in winter and spring. The onset of the disease starts after childbirth, of which 82% are from 1 to 7 days after delivery and 18% are after 7 days. And 2 days after delivery is the most, accounting for 16%. Cows with milk yield of 5000 kg had no disease; cows with milk yield of 5000-6000 kg had 29% disease; cows with milk yield of 6000-7000 kg had 26% disease; cows with milk yield of 7000 kg or more had 45% disease. The higher the yield, the more morbidity. The higher the amount of concentrate fed to cows in the dry milk period, the more the disease. 2. Etiology Excessive feeding of concentrate, high energy and protein levels in the diet of cows in the dry milk period, and the actual amount of food eaten by cows exceeding the actual nutritional needs are the main causes of obesity syndrome in cows. Unbalanced diets, improper coarse to concentrate ratio, high yielding dairy farms, high milk production. As milk is exchanged for feed, the higher the milk production, the more concentrate is exchanged and the concentrate is abundant; in addition, other feeds such as sugar dregs, bean curd dregs and tuberous feeds are abundant, so the proportion of concentrate for dry cows increases; some cattle farms have poor feed conditions, especially the lack of coarse feed, the lack of hay all year round, and the simple variety of feeds, when feeding, in order to be able to supplement the lack or lack of coarse feed, so the diet increases the concentrate Feeding amount. In cattle farms where lactating cows are mixed with dry cows, it is often found that dry cows grab the concentrate of lactating cows, resulting in more concentrate feeding; there are also cattle farms that do not understand the feeding method of dry cows and simply believe that dry cows can produce high yields if they are obese, so there are no strict standards for concentrate feeding and the phenomenon of fat chasing with extra feed. 3, clinical symptoms (1) acute: with the cow giving birth and show symptoms, the affected cows are depressed, appetite wasted, rumen peristalsis weak; less milk or no milk, visible mucosa cyanosis, yellow staining. Body temperature rises initially (39.5~40℃ or more). The gait is strongly restrained, the gaze is dull, and the external reaction is weak. In cases with diarrhea, yellowish-brown, foul-smelling loose stools are excreted. No response to drugs, die within 2-3 days or late lying down and eliminated. (2) Sub-acute: Most of the disease develops 3 days after delivery, and the affected cattle mainly present as postpartum ketosis. Appetite is reduced or abolished, milk production is reduced, feces is low and dry, urine is acidic, pH 6.0, with ketone smell. Ketone body test is positive. The disease is prolonged and is progressively wasting. In some cases, mastitis and meconium retention are also associated with the disease. When there is mastitis, the udder is swollen, the milk is purulent or extremely thin, yellow water-like, and the milk is positive for ketone bodies. A large amount of brown, foul-smelling milk accumulates in the birth canal. Drug treatment is ineffective, late lying on the ground, moaning, grinding teeth, and dying of exhaustion. 4.Diagnosis Diagnosis can be confirmed based on epidemiology, clinical symptoms, and ketone body test. 5.Treatment The purpose of drug treatment is to inhibit lipolysis, reduce the accumulation of fatty acids in the liver, and accelerate the utilization of lipids; the principles are detoxification and liver protection, and glucose supplementation to alleviate the decline of blood glucose. (1) Raise blood glucose concentration and supplement glucose source: 50% glucose solution 500-1000ml, intravenously. 50% dextran, the first amount is 1500ml, then change to 500ml, twice or three times a day, intravenously. Sodium propionate 114-228g or propylene glycol 117-342g, taken internally twice a day, before taking the drug, 50% dextrose can be injected intravenously, and its effect is better. (2) To promote fat oxidation, use lipolytic preparations: 50% choline chloride powder 50-60g, once taken internally. Also available 10% choline chloride solution 250ml, one subcutaneous injection. It can promote fatty acid oxidation and lipoprotein synthesis, and has significant lipolytic effect. Calcium pantothenate 200-300mg, prepared into 10% solution, once intravenously for 3 days. Vitamin B complex solution 200-250ml, once by infusion, twice a day. It can promote appetite and improve rumen function. Niacin 12～15g, once internal, for 3～5 days, can resist lipolysis and anti-ketone body production after instillation. (3) symptomatic treatment: to prevent secondary infection, antibiotics such as tetracycline, chlortetracycline, intravenous injection; to prevent azotemia, available 5% sodium bicarbonate solution 500 ~ 1 000mL, once intravenous injection, for jaundiced cattle, magnesium sulfate 300 ~ 500g, with water infusion, for 3 days.