The first question asked by many patients in outpatient or hospitalized settings is often “How did I get this disease? Is it related to iodized salt? Is it genetically related?” It is true that the use of iodized salt has played a key role in the prevention and treatment of endemic (iodine-deficient areas) nodular goiter, which has decreased, but the incidence of sporadic goiter, as well as the incidence of thyroid cancer and immunogenic thyroid disorders, has shown signs of increasing. This may have something to do with our current deeper understanding of thyroid disease and the sophistication of our testing equipment, but the impact of salt iodization on the changing epidemiological characteristics of the thyroid gland still cannot be ruled out. The genetic characterization of thyroid diseases is a relatively certain conclusion, especially as thyroid-immune diseases are genetically more pronounced, and here it is important to pay attention to the regular testing of female family members in the family.