Changes in the color of the face often indicate some internal organ pathology, such as yellow face, indicating liver damage, and a dark face, often indicating kidney disease. The most common is the face of chronic kidney disease caused by chronic kidney failure, manifested as a dark face, gray skin without luster. It is recommended to visit the nephrology department of the hospital to check kidney function, blood count, parathyroid hormone, calcium, phosphorus and other indicators to assess the physical condition and make a clear diagnosis for symptomatic treatment.