Usually antinuclear antibodies are checked for autoimmune diseases, and their test results can provide diagnostic clues for diseases such as systemic lupus erythematosus, mixed connective tissue disease, dry syndrome, drug-induced lupus, and polymyositis. Antinuclear antibody is a general term for a group of autoantibodies, mainly found in human serum, which show different positive rates in a variety of autoimmune diseases, among which the positive rate of SLE is higher, but antinuclear antibody is not a specific antibody for SLE. In addition to SLE, antinuclear antibodies also have clinical significance in mixed connective tissue disease, dry syndrome, drug-induced lupus, polymyositis and other diseases. It is recommended that patients who need to test for antinuclear antibodies go to the Department of Rheumatology and Immunology or other related departments in regular hospitals for detailed consultation.