HPV is a class of viruses with strict host range and tissue specificity that infects human skin and mucosal epithelial cells and parasitizes the squamous and columnar epithelium, causing benign and malignant lesions at the site of infection. Diseases caused by HPV can be classified by site: 1, skin: common warts, flat warts, plantar warts. 2.Anal and genitourinary tract: skin squamous cell carcinoma, condyloma acuminata, Bowen’s disease, female pubic cancer, cervical cancer, penile cancer, testicular cancer, prostate cancer, rectal cancer. 3.Respiratory tract: laryngeal papilloma, laryngeal squamous cell tumor, tonsillar phosphorous squamous cell carcinoma, lung squamous cell carcinoma. 4.Ocular: corneal conjunctival papilloma, corneal carcinoma. 5, oral and gastrointestinal tract: oral acromegaly, oral common warts, oral papilloma, oral squamous cell carcinoma, oropharyngeal cancer, esophageal squamous cell carcinoma.