Breast nodules grade 3-4 can be vaccinated with the New Crown vaccine. According to the “Guidelines on Contraindications and Precautions for Neocoronavirus Vaccination (Third Edition)”, contraindications include: uncontrolled epilepsy and other severe neurological diseases; vaccine allergy; fever, acute exacerbation of disease; pregnant women; thrombocytopenia or bleeding disorders; lymphoma and leukemia; uncontrolled autoimmune diseases. Breast nodules are not a contraindication to the New Crown vaccine, and there is no evidence that New Crown vaccination causes breast nodule enlargement, so it is possible to vaccinate. Patients with grade 3-4 breast nodules need regular ultrasound and molybdenum target examinations to follow up the changes in the nodules, and biopsy and surgery to clarify the nature of the nodules if necessary. The Neocolla vaccine is an effective means of preventing Neocolla virus, so patients are advised to get vaccinated in a timely manner.