IgA nephropathy renal puncture results Hass’s pathologic grading is usually categorized into five grades, grade I is mild lesions, grade II is focal segmental glomerulosclerosis, grade III is focal proliferative glomerulonephritis, grade IV is diffuse proliferative glomerulonephritis, and grade V is advanced chronic glomerulonephritis. 1. Grade I (mild lesions): glomeruli with only mild increase in mesangial cells, no segmental sclerosis, no crescent. 2. Grade II (focal segmental glomerulosclerosis): glomerular lesions similar to primary focal segmental glomerulosclerosis, accompanied by mild increase in glomerular mesangial cells, no crescent. 3. Grade III (focal proliferative glomerulonephritis): ≤50% of glomerular mesangial cell hyperplasia, may be accompanied by endothelial cell hyperplasia, the vast majority of cases are segmental hyperplasia, and crescents can be seen. 4.Grade IV (diffuse proliferative glomerulonephritis): >50% of glomerular mesangial cell proliferation, with or without endothelial cell proliferation, the cell proliferation may be segmental or globular, and crescent can be seen. 5.Grade V (advanced chronic glomerulonephritis): ≥40% of glomerulosclerosis, the rest may show various glomerulopathy as mentioned above. ≥40% of cortical renal tubules are atrophied or disappeared. The grading of renal puncture results can help doctors determine the severity of the disease, and it is recommended that patients with IgA nephropathy should seek medical treatment in time, undergo renal puncture biopsy as prescribed by the doctor if necessary, and actively cooperate with the doctor for standardized treatment.