The solution to shortness of breath when lying down is first to find the primary cause of the disease and treat the cause, and second, to relieve the symptoms by inhaling oxygen, using medication, and changing body position. The existence of shortness of breath when lying down, there may be the existence of heart failure, may also be caused by chronic obstructive pulmonary disease and so on. To relieve the symptoms, the first step is to clarify the primary disease and treat the primary disease, and the second step is to address the patient’s symptoms, which can be targeted. Symptoms caused during acute attacks of heart failure can be treated by applying diuretics such as furosemide and cardiotonic drugs such as digoxin to treat the primary disease. Symptoms caused by acute exacerbation of chronic obstructive pulmonary disease can be treated with antibiotics for anti-inflammation, ambroxol for antispasmodic and asthma, budesonide nebulization and other ways. The above medications should be used under medical supervision. Oxygen can be administered to relieve shortness of breath and improve hypoxia. Changing the patient’s position to semi-recumbent or sitting, and dropping both lower limbs in heart failure patients can also help to relieve the symptoms of chest tightness and shortness of breath. It is recommended to go to the hospital for diagnosis of shortness of breath while lying down, so as to clarify the cause of the disease and choose a reasonable treatment plan according to the condition.